Expression of transforming growth factor-? in hepatoblastoma
نویسندگان
چکیده
منابع مشابه
Inducible Expression of Transforming Growth Factor
Transforming growth factor 1 (TGF1) acts as a tumor suppressor at early stages of carcinogenesis, however, it has also been suggested to promote tumor progression at late stages. To determine at which stage and by what mechanisms this functional switch occurs, we have generated gene-switch-TGF1 mice in which TGF1 transgene expression can be induced in skin tumors at specific stages. These mice ...
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Background: Vitiligo is characterized by selective destruction of melanocytes. Transforming growth factor beta 1 (TGFβ 1) is the main product of regulatory T cells (Tregs) which are deficient in vitiligo. Thus, lower levels of serum TGFβ 1 are expected in vitiligo. However, TGFβ 1 is a keratinocytederived cytokine with inhibitory effect on melanocyte activity. Thus it may be expected to be high...
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The induction of adenocarcinomas in the glandular stomach of the adult male Wistar rat by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) was used as a model to study the expression of the growth promoting peptide, transforming growth factor alpha (TGF alpha), during experimental gastric carcinogenesis. TGF alpha was identified using the monoclonal antibody Ab-2 and standard immunohistochemistry, t...
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Objective: Helicobacter pylori has a well-established role in the development of gastric cancer. In vitro studies reveal increased proliferation of the gastric mucosa in the presence of H. pylori infection. It has been also shown that production of some cytokines, such as interleukin-1 beta (IL-1b) is in...
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EGFR is a key molecule in cancer cells. EGFR signaling was shown to promote tumor cell proliferation and survival, invasion and angiogenesis and mediate resistance to treatment, including ionizing radiation in preclinical models. We extracted proteins from astrocytoma (III and IV) oligodendroglioma(IV) tumors and normal brain tissues and then evaluated the protein purity by Bradford test ...
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ژورنال
عنوان ژورنال: Cancer
سال: 1998
ISSN: 0008-543X,1097-0142
DOI: 10.1002/(sici)1097-0142(19980815)83:4<690::aid-cncr9>3.0.co;2-o